Antiviral pathway activation in patients with chronic fatigue syndrome and acute infection

被引:12
作者
Gow, JW
Simpson, K
Behan, PO
Chaudhuri, A
McKay, IC
Behan, WMH
机构
[1] Univ Glasgow, Dept Neurol, Glasgow G12 8QQ, Lanark, Scotland
[2] Univ Glasgow, Dept Pathol, Glasgow G12 8QQ, Lanark, Scotland
[3] Univ Glasgow, Dept Immunol, Glasgow G12 8QQ, Lanark, Scotland
关键词
D O I
10.1086/324357
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Gene expression of key enzymes in 2 antiviral pathways (ribonuclease latent [RNase L] and RNA-regulated protein kinase [PKR]) was compared in 22 patients with chronic fatigue syndrome (CFS), 10 patients with acute gastroenteritis, and 21 healthy volunteers. Pathway activation in the group of patients with infections differed significantly from that of the other 2 groups, in whom there was no evidence of upregulation. Therefore, assay of activation is unlikely to provide the basis for a diagnostic test for CFS.
引用
收藏
页码:2080 / 2081
页数:2
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