Characterization of novel macrolide toxins, mycolactones A and B, from a human pathogen, Mycobacterium ulcerans

被引:62
作者
Gunawardana, G
Chatterjee, D
George, KM
Brennan, P
Whittern, D
Small, PLC
机构
[1] NIAID, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA
[2] Abbott Labs, Div Pharmaceut Prod, Abbott Pk, IL 60046 USA
[3] Colorado State Univ, Dept Microbiol, Ft Collins, CO 80523 USA
关键词
D O I
10.1021/ja990017l
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:6092 / 6093
页数:2
相关论文
共 8 条
[1]  
[Anonymous], MACROLIDE ANTIBIOTIC
[2]  
BAX A, 1986, J AM CHEM SOC, V108, P2039
[3]   STRUCTURE DETERMINATION OF A TETRASACCHARIDE - TRANSIENT NUCLEAR OVERHAUSER EFFECTS IN THE ROTATING FRAME [J].
BOTHNERBY, AA ;
STEPHENS, RL ;
LEE, JM ;
WARREN, CD ;
JEANLOZ, RW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (03) :811-813
[4]   Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence [J].
Cole, ST ;
Brosch, R ;
Parkhill, J ;
Garnier, T ;
Churcher, C ;
Harris, D ;
Gordon, SV ;
Eiglmeier, K ;
Gas, S ;
Barry, CE ;
Tekaia, F ;
Badcock, K ;
Basham, D ;
Brown, D ;
Chillingworth, T ;
Connor, R ;
Davies, R ;
Devlin, K ;
Feltwell, T ;
Gentles, S ;
Hamlin, N ;
Holroyd, S ;
Hornby, T ;
Jagels, K ;
Krogh, A ;
McLean, J ;
Moule, S ;
Murphy, L ;
Oliver, K ;
Osborne, J ;
Quail, MA ;
Rajandream, MA ;
Rogers, J ;
Rutter, S ;
Seeger, K ;
Skelton, J ;
Squares, R ;
Squares, S ;
Sulston, JE ;
Taylor, K ;
Whitehead, S ;
Barrell, BG .
NATURE, 1998, 393 (6685) :537-+
[5]  
Connor DH, 1965, Int J Lepr, V33, P698
[6]   Partial purification and characterization of biological effects of a lipid toxin produced by Mycobacterium ulcerans [J].
George, KM ;
Barker, LP ;
Welty, DM ;
Small, PLC .
INFECTION AND IMMUNITY, 1998, 66 (02) :587-593
[7]   Mycolactone:: A polyketide toxin from Mycobacterium ulcerans required for virulence [J].
George, KM ;
Chatterjee, D ;
Gunawardana, G ;
Welty, D ;
Hayman, J ;
Lee, R ;
Small, PLC .
SCIENCE, 1999, 283 (5403) :854-857
[8]  
MULLER L, 1979, J AM CHEM SOC, V101, P4481