Protective immunity to Shiga-like toxin I following oral immunization with Shiga-like toxin I B-subunit-producing Vibrio cholerae CVD 103-HgR

被引：51

作者：

Acheson, DWK ^{[1
]}

Levine, MM ^{[1
]}

Kaper, JB ^{[1
]}

Keusch, GT ^{[1
]}

机构：

[1] UNIV MARYLAND, CTR VACCINE DEV, BALTIMORE, MD 21201 USA

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 01期

关键词：

D O I：

10.1128/IAI.64.1.355-357.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study addresses a mechanism for inducing systemic immunity to Shiga-like toxins by oral administration of a Shiga-like toxin I B-subunit-expressing Vibrio cholerae vaccine strain [CVD 103-HgR(pDA60)]. Two sets of three rabbits were given either CVD 103-HgR or CVD 103-HgR(pDA60) orally. All rabbits immunized with CVD 103-HgR(pDA60) developed neutralizing serum antibodies to Shiga like toxin I. None of the controls developed such antibodies.

引用

页码：355 / 357

页数：3

共 23 条

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