The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells Implications for pancreatic cancer-driven immunosuppression

被引：17

作者：

Basso, Daniela ^{[1
]}

Fogar, Paola ^{[1
]}

Plebani, Mario ^{[1
]}

机构：

[1] Univ Hosp Padova, Dept Lab Med, Padua, Italy

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 06期

关键词：

CD8(+) T cells; CTLA4; dendritic cells; myeloid-derived suppressive cells; pancreatic ductal adenocarcinoma; PDL1; S100; proteins; CARCINOGENESIS;

D O I：

10.4161/onci.24441

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

An expansion of different myeloid derived suppressive cell (MDSC) subsets can be detected in the blood and secondary lymphoid organs of early and advanced pancreatic ductal adenocarcinoma (PDAC) patients. Double negative (CD14(-)HLA-DR-) MDSCs are frequently induced by PDACs. In addition, by releasing S100A8 and S100A9, advanced PDAC lesions cause an expansion of highly immunosuppressive CD33(+)CD14(+)HLA-DR- monocytic MDSCs expressing low levels of cytotoxic T lymphocyte antigen 4 (CTLA4) on the cell surface.

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