Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp: an fMRI study

被引:89
作者
Oga, T
Honda, M
Toma, K
Murase, N
Okada, T
Hanakawa, T
Sawamoto, N
Nagamine, T
Konishi, J
Fukuyama, H
Kaji, R
Shibasaki, H
机构
[1] Kyoto Univ, Grad Sch Med, Human Brain Res Ctr, Dept Brain Pathophysiol,Sakyo Ku, Kyoto 6068507, Japan
[2] Kyoto Univ, Grad Sch Med, Dept Neurol, Sakyo Ku, Kyoto 6068507, Japan
[3] Kyoto Univ, Grad Sch Med, Dept Nucl Med, Sakyo Ku, Kyoto 6068507, Japan
[4] Natl Inst Physiol Sci, Lab Cerebral Integrat, Okazaki, Aichi 444, Japan
[5] Univ Tokushima, Sch Med, Dept Neurol, Tokushima 770, Japan
关键词
writer's cramp; voluntary muscle relaxation; central motor control; inhibitory motor system; event-related functional MRI;
D O I
10.1093/brain/awf083
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Although it is hypothesized that there is abnormal motor inhibition in patients with dystonia, the question remains as to whether the mechanism related to motor inhibition is specifically impaired. The objective of the present study was to clarify the possible abnormalities of the mechanisms underlying voluntary muscle relaxation during motor preparation and execution in patients with writer's cramp, using event-related functional MRI. Eight patients with writer's cramp and 12 age-matched control subjects participated in the study. Two motor tasks were employed as an experimental paradigm. In the relaxation task, subjects were asked to hold their right wrist in the horizontal plane by maintaining moderate contraction of wrist extensor muscles in the premotor phase; they relaxed those muscles voluntarily just once during each fMRI scanning session. In the contraction task, subjects extended the right wrist voluntarily from the same premotor state as for the relaxation task. Five axial images covering the primary sensorimotor cortex (SMC) and supplementary motor area (SMA) were obtained once every second. Activated volumes in the left SMC and the SMA were significantly reduced in patients for both muscle relaxation and contraction tasks. These data suggest that there is impaired activation in both SMC and SMA in voluntary muscle relaxation and contraction in patients with writer's cramp. This implies that abnormalities of both inhibitory and excitatory mechanisms in motor cortices might play a role in the pathophysiology of focal dystonia.
引用
收藏
页码:895 / 903
页数:9
相关论文
共 45 条
[1]  
BARKER AT, 1987, NEUROSURGERY, V20, P100
[2]   The pathophysiology of primary dystonia [J].
Berardelli, A ;
Rothwell, JC ;
Hallett, M ;
Thompson, PD ;
Manfredi, M ;
Marsden, CD .
BRAIN, 1998, 121 :1195-1212
[3]   Botulinum toxin does not reverse the cortical dysfunction associated with writer's cramp - A PET study [J].
CeballosBaumann, AO ;
Sheean, G ;
Passingham, RE ;
Marsden, CD ;
Brooks, DJ .
BRAIN, 1997, 120 :571-582
[4]   OVERACTIVE PREFRONTAL AND UNDERACTIVE MOTOR CORTICAL AREAS IN IDIOPATHIC DYSTONIA [J].
CEBALLOSBAUMANN, AO ;
PASSINGHAM, RE ;
WARNER, T ;
PLAYFORD, ED ;
MARSDEN, CD ;
BROOKS, DJ .
ANNALS OF NEUROLOGY, 1995, 37 (03) :363-372
[5]   Impaired inhibition in writer's cramp during voluntary muscle activation [J].
Chen, R ;
Wassermann, EM ;
Canos, M ;
Hallett, M .
NEUROLOGY, 1997, 49 (04) :1054-1059
[6]   Movement-related cortical potentials in writer's cramp [J].
Deuschl, G ;
Toro, C ;
Matsumoto, J ;
Hallett, M .
ANNALS OF NEUROLOGY, 1995, 38 (06) :862-868
[7]  
Fahn S, 1988, Adv Neurol, V50, P1
[8]   Diminished regional cerebral blood flow response to vibration in patients with blepharospasm [J].
Feiwell, RJ ;
Black, KJ ;
McGee-Minnich, LA ;
Snyder, AZ ;
MacLeod, AM ;
Perlmutter, JS .
NEUROLOGY, 1999, 52 (02) :291-297
[9]   ABNORMAL MOVEMENT-RELATED POTENTIALS IN PATIENTS WITH LESIONS OF BASAL GANGLIA AND ANTERIOR THALAMUS [J].
FEVE, A ;
BATHIEN, N ;
RONDOT, P .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1994, 57 (01) :100-104
[10]   Impairment of cortical inhibition in writer's cramp as revealed by changes in electromyographic silent period after transcranial magnetic stimulation [J].
Filipovic, SR ;
Ljubisavljevic, M ;
Svetel, M ;
Milanovic, S ;
Kacar, A ;
Kostic, VS .
NEUROSCIENCE LETTERS, 1997, 222 (03) :167-170