Hemin induces germ tube formation in Candida albicans

被引：28

作者：

Casanova, M ^{[1
]}

Cervera, AM ^{[1
]}

Gozalbo, D ^{[1
]}

Martinez, JP ^{[1
]}

机构：

[1] UNIV VALENCIA, FAC FARM, DEPT MICROBIOL & ECOL, BURJASSOT, VALENCIA, SPAIN

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 10期

关键词：

D O I：

10.1128/IAI.65.10.4360-4364.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hemin induced germination of Candida albicans blastoconidia when cells grown up to the early exponential phase were shifted from 28 to 37 degrees C (70 to 75% of cells exhibited germ tubes). N-Acetyl-D-glucosamine (GlcNAc), another inducer of myceliation in this fungus, caused a similar effect. The combination of hemin and GlcNAc resulted in a higher percentage (95%) of blastoconidial germination. These results suggest that in addition to temperature, hemin levels and carbon source may coordinately regulate the expression of subsets of genes involved in the yeast-to-mycelium transition in C. albicans.

引用

页码：4360 / 4364

页数：5

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