A weakly antimalarial biflavanone from Rhus retinorrhoea

被引：48

作者：

Ahmed, MS

Galal, AM

Ross, SA

Ferreira, D

ElSohly, MA

Ibrahim, ARS

Mossa, JS

El-Feraly, FS

机构：

[1] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh, Saudi Arabia

[3] Univ Mississippi, Dept Pharmacognosy, University, MS 38677 USA

[4] Univ Mississippi, Sch Pharm, Dept Pharmaceut, University, MS 38677 USA

[5] Tanta Univ, Coll Pharm, Dept Pharmacognosy, Tanta, Egypt

来源：

PHYTOCHEMISTRY | 2001年 / 58卷 / 04期

基金：

美国农业部;

关键词：

Rhus retinorrhoea; Anacardiaceae; biflavonoids; biflavanone; tetrahydroamentoflavone; antimicrobial activity; antimalarial activity;

D O I：

10.1016/S0031-9422(01)00244-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The biflavanone (2S,2 "S)-7,7 " -di-O-methyltetrahydroamentoflavone and five known flavonoids, 7-O-methylnaringenin, 7,3'-O-dimethylquercetin, 7-O-methylapigenin, 7-O-methylluteolin, and eriodictyol were isolated from the leaves of Rhus retinorrhoea Steud, Ex Olive. The biflavanone exhibited moderate antimalarial activity with IC50 0.98 mug/ml against Plasmodium falciparum (W2 Clone) and weak activity against P. falciparum (D6 Clone) with IC50 2.8 mug/ml. Nevertheless, it did not display any cytotoxicity. 7-O-Methylnaringenin showed weak antimicrobial activity against Candida albicans, C. krusei, Staphylococcus aureus, Mycobacterium smegmatis, M. intracellulare, and M. xenopi with MIC similar to 100 mug/ml. Characterization of each compound was based on spectral analysis and comparison with reported data. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：599 / 602

页数：4

共 17 条

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