Romiplostim

被引：39

作者：

Cines, Douglas B. ^{[1
]}

Yasothan, Uma ^{[2
]}

Kirkpatrick, Peter

机构：

[1] Hosp Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] IMS Hlth, London NW1 6JB, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 11期

关键词：

D O I：

10.1038/nrd2741

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In August 2008, romiplostim (Nplate; Amgen), a thrombopoietin receptor agonist, was approved by the US FDA for the treatment of thrombocytopaenia in patients with chronic immune thrombocytopaenic purpura who have had an insufficient response to corticosteroids, immunoglobulins or splenectomy.

引用

页码：887 / 888

页数：2

共 17 条

[1] MECHANISMS OF THROMBOCYTOPENIA IN CHRONIC AUTOIMMUNE THROMBOCYTOPENIC PURPURA - EVIDENCE OF BOTH IMPAIRED PLATELET PRODUCTION AND INCREASED PLATELET CLEARANCE [J].

BALLEM, PJ ;

SEGAL, GM ;

STRATTON, JR ;

GERNSHEIMER, T ;

ADAMSON, JW ;

SLICHTER, SJ .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (01) :33-40

[2] AMG531 stimulates megakaryopoiesis in vitro by binding to Mp1 [J].

Broudy, VC ;

Lin, NL .

CYTOKINE, 2004, 25 (02) :52-60

[3] Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura [J].

Bussel, James B. ;

Cheng, Gregory ;

Saleh, Mansoor N. ;

Psaila, Bethan ;

Kovaleva, Lidia ;

Meddeb, Balkis ;

Kloczko, Janusz ;

Hassani, Habib ;

Mayer, Bhabita ;

Stone, Nicole L. ;

Arning, Michael ;

Provan, Drew ;

Jenkins, Julian M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (22) :2237-2247

[4] AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP [J].

Bussel, James B. ;

Kuter, David J. ;

George, James N. ;

McMillan, Robert ;

Aledort, Louis M. ;

Conklin, George T. ;

Lichtin, Alan E. ;

Lyons, Roger M. ;

Nieva, Jorge ;

Wasser, Jeffrey S. ;

Wiznitzer, Israel ;

Kelly, Reggie ;

Chen, Chien-Feng ;

Nichol, Janet L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (16) :1672-1681

[5] Medical progress: Immune thrombocytopenic purpura. [J].

Cines, DB ;

Blanchette, VS .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (13) :995-1008

[6] The bleeding risk and natural history of idiopathic thrombocytopenic purpura in patients with persistent low platelet counts [J].

Cohen, YC ;

Djulbegovic, B ;

Shamai-Lubovitz, O ;

Mozes, B .

ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (11) :1630-1638

[7] The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura [J].

Cooper, N ;

Stasi, R ;

Cunningham-Rundles, SS ;

Feuerstein, MA ;

Leonard, JP ;

Amadori, S ;

Bussel, JB .

BRITISH JOURNAL OF HAEMATOLOGY, 2004, 125 (02) :232-239

[8]

*FOOD DRUG ADM, 2008, FDA LAB INF

[9] Rituximab efficacy and. safety in adult splenectomy candidates with chronic immune thrombocytopenic purpura:: results of a prospective multicenter phase 2 study [J].

Godeau, Bertrand ;

Porcher, Raphael ;

Fain, Olivier ;

Lefrere, Francois ;

Fenaux, Pierre ;

Cheze, Stephane ;

Vekhoff, Anne ;

Chauveheid, Marie-Paule ;

Stirnemann, Jerome ;

Galicier, Lionel ;

Bourgeois, Emmanuelle ;

Haiat, Stephanie ;

Varet, Bruno ;

Leporrier, Michel ;

Papo, Thomas ;

Khellaf, Mehdi ;

Michel, Marc ;

Bierling, Philippe .

BLOOD, 2008, 112 (04) :999-1004

[10]

HOLLEY B, 2008, OPPENHEIMER EQUITY R

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