Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives

被引：13

作者：

Bongartz, JP

Stokbroekx, R

Van der Aa, M

Luyckx, M

Willems, M

Ceusters, M

Meerpoel, L

Smets, G

Jansen, T

Wouters, W

Bowden, C

Valletta, L

Herb, M

Tominovich, R

Tuman, R

机构：

[1] Janssen Res Fdn, B-2340 Beerse, Belgium

[2] RW Johnson Pharmaceut Res Inst, Spring House, PA 19477 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)00805-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

General screening for inhibitors of microvessel growth in vitro in the rat aortic ring assay led to the discovery of a novel series of thiadiazole pyridazine compounds with potential anti-angiogenic activity. Chemical optimization produced orally active compounds with potent in vitro and in vivo anti-angiogenesis and anti-tumor activities. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：589 / 591

页数：3

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