Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo

被引：33

作者：

Bergquam, EP

Avery, N

Shiigi, SM

Axthelm, MK

Wong, SW

机构：

[1] Oregon Reg Primate Res Ctr, Div Pathobiol & Immunol, Beaverton, OR 97006 USA

[2] Oregon Hlth Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 09期

关键词：

D O I：

10.1128/JVI.73.9.7874-7876.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recent DNA sequence analysis indicates that rhesus rhadinovirus (RRV) is a member of the lymphotropic gamma-2 herpesvirus family. To determine if RRV is lymphotropic, peripheral blood mononuclear cells from naturally infected monkeys were separated by immunomagnetic bead depletion and analyzed for the presence of RRV by virus isolation and nested PCR The recovery and consistent detection of RRV in the CD20(+)-enriched fraction clearly demonstrates that B lymphocytes are a major site of virus persistence.

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收藏

页码：7874 / 7876

页数：3

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