Searching for the hereditary causes of renal-cell carcinoma

被引：140

作者：

Pavlovich, CP

Schmidt, LS

机构：

[1] Johns Hopkins Bayview Med Ctr, Brady Urol Inst, Baltimore, MD 21224 USA

[2] NCI, Basic Res Program, SAIC Frederick Inc, Frederick, MD 21702 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1364

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Families with hereditary predispositions to cancer continue to provide a unique opportunity for the identification and characterization of genes involved in carcinogenesis. A surprising number of genetic syndromes predispose to the development of renal-cell carcinoma, and already genes associated with five of these syndromes have been identified - VHL, MET, FH, BHD and HRPT2. These very different genes and the biochemical pathways in which they participate raise interesting questions about the development of renal cancers and could lead to new therapeutic approaches in the near future. So, what is known about hereditary renal cancer at present?

引用

页码：381 / 393

页数：13

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