The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

被引：106

作者：

Luc, Sidinh ^{[1
,2
,3
]}

Luis, Tiago C. ^{[1
]}

Boukarabila, Hanane ^{[1
]}

Macaulay, Iain C. ^{[1
]}

Buza-Vidas, Natalija ^{[1
,4
]}

Bouriez-Jones, Tiphaine ^{[1
]}

Lutteropp, Michael ^{[1
,3
]}

Won, Petter S. ^{[1
]}

Loughran, Stephen J. ^{[1
]}

Mead, Adam J. ^{[1
]}

Hultquist, Anne ^{[2
]}

Brown, John ^{[3
]}

Mizukami, Takuo ^{[1
]}

Matsuoka, Sahoko ^{[1
]}

Ferry, Helen ^{[1
]}

Anderson, Kristina ^{[2
]}

Duarte, Sara ^{[1
]}

Atkinson, Deborah ^{[1
]}

Soneji, Shamit ^{[3
]}

Domanski, Aniela ^{[1
]}

Farley, Alison ^{[4
]}

Sanjuan-Pla, Alejandra ^{[4
]}

Carella, Cintia ^{[5
]}

Patient, Roger ^{[3
]}

de Bruijn, Marella ^{[3
]}

Enver, Tariq ^{[3
]}

Nerlov, Claus ^{[4
]}

Blackburn, Clare ^{[4
]}

Godin, Isabelle ^{[6
,7
,8
]}

Jacobsen, Sten Eirik W. ^{[1
,2
,3
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Haematopoiet Stem Cell Lab, Weatherall Inst Mol Med, Oxford OX3 9DU, England

[2] Lund Univ, Hematopoiet Stem Cell Lab, Lund Stem Cell Ctr, Lund, Sweden

[3] Univ Oxford, MRC, Mol Haematol Unit, Weatherall Inst Mol Med, Oxford, England

[4] Univ Edinburgh, Inst Stem Cell Res, MRC, Ctr Regenerat Med, Edinburgh, Midlothian, Scotland

[5] European Mol Biol Lab, Mouse Biol Unit, Monterotondo, Italy

[6] INSERM, U1009, Villejuif, France

[7] Inst Gustave Roussy, Villejuif, France

[8] Univ Paris 11, Orsay, France

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 04期

基金：

英国医学研究理事会;

关键词：

STEM-CELLS; HEMATOPOIETIC PROGENITORS; DENDRITIC CELLS; IDENTIFICATION; MARKS; SPECIFICATION; PRECURSORS; MPL; MAP;

D O I：

10.1038/ni.2255

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. These potentials were identical to those of candidate thymus-seeding progenitors in the bone marrow, which were closely related at the molecular level. Our findings establish the distinct lineage-restriction stage at which the T cell lineage-commitment process transits from the bone marrow to the remote thymus.

引用

页码：412 / 419

页数：8

共 44 条

[1] Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential:: A revised road map for adult blood lineage commitment [J].