Photoswitched DNA-binding of a photochromic spiropyran

被引：175

作者：

Andersson, Johanna ^{[1
]}

Li, Shiming ^{[1
]}

Lincoln, Per ^{[1
]}

Andreasson, Joakim ^{[1
]}

机构：

[1] Chalmers Univ Technol, Dept Biol & Chem Engn, SE-41296 Gothenburg, Sweden

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 36期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1021/ja801968f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The dramatically different DNA-binding properties of the two isomeric forms of a photochromic spiropyran have been demonstrated, enabling photoswitched DNA binding. The closed, UV-absorbing form shows no signs of interaction with DNA. Upon UV exposure the spiropyran is isomerized to the open form that binds to DNA by intercalation. The process is fully reversible as the corresponding dissociation process is induced by visible light. Copyright © 2008 American Chemical Society.

引用

页码：11836 / 11837

页数：2

共 21 条

[1]

Asanuma H, 2001, ANGEW CHEM INT EDIT, V40, P2671, DOI 10.1002/1521-3773(20010716)40:14<2671::AID-ANIE2671>3.0.CO

[2]

2-Z

[3]

Asanuma H, 1999, ANGEW CHEM INT EDIT, V38, P2393, DOI 10.1002/(SICI)1521-3773(19990816)38:16<2393::AID-ANIE2393>3.0.CO

[4]

2-7

[5]

AUBARD J, 1999, ORGANIC PHOTOCHROMIC, V2, P369

[6]

Bertelson RC, 1999, T APPL CHEM, V1, P11

[7] Molecular recognition of DNA by small molecules [J].

Dervan, PB .

BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (09) :2215-2235

[8] Photoswitchable molecular glue for DNA [J].

Dohno, Chikara ;

Uno, Shin-Nosuke ;

Nakatani, Kazuhiko .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (39) :11898-+

[9] Photoregulation of DNA triplex formation by azobenzene [J].

Liang, XG ;

Asanuma, H ;

Komiyama, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (09) :1877-1883

[10] Azobenzene-tethered T7 promoter for efficient photoregulation of transcription [J].

Liu, MZ ;

Asanuma, H ;

Komiyama, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (03) :1009-1015

← 1 2 3 →