MicroRNAs in Cerebral Ischemia

被引：28

作者：

Lim, Kai-Ying ^{[1
]}

Chua, Jia-Hui ^{[1
]}

Tan, Jun-Rong ^{[1
]}

Swaminathan, Priyadharshni ^{[1
]}

Sepramaniam, Sugunavathi ^{[1
]}

Armugam, Arunmozhiarasi ^{[1
]}

Wong, Peter Tsun-Hon ^{[2
]}

Jeyaseelan, Kandiah ^{[1
]}

机构：

[1] Natl Univ Singapore, Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Stroke Program,Dept Biochem, Singapore 117597, Singapore

[2] Natl Univ Singapore, Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Stroke Program,Dept Pharmacol, Singapore 117597, Singapore

来源：

TRANSLATIONAL STROKE RESEARCH | 2010年 / 1卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

MicroRNA; Gene; Cerebral ischemia; MCAo; Biomarkers; Acute phase;

D O I：

10.1007/s12975-010-0035-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Pathogenesis of cerebral ischemia has so far been described in the context of proteins and the pathways that they regulate. The discovery of biomarkers has also been focussed mainly on proteins and to some extent on the mRNAs that encode them. The knowledge on the role of microRNAs in understanding the pathogenesis of cerebral ischemia is still at its infancy. In this study, using rat models subjected to middle cerebral artery occlusion, we have profiled the microRNAs at different reperfusion times (0 to 48 h) to understand the progression of cerebral ischemia. We have also attempted to correlate the expression of microRNAs to treatment with an NMDA antagonist (MK801) and to protein expression with the hope of demonstrating the potential use of microRNAs as early biomarkers of stroke.

引用

页码：287 / 303

页数：17

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