Confocal imaging of benign and malignant proliferative skin lesions in vivo

被引：3

作者：

Gonzalez, S ^{[1
]}

Rajadhyaksha, M ^{[1
]}

Anderson, RR ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Dermatol,Wellman Labs Photomed, Boston, MA 02114 USA

来源：

LASERS IN SURGERY: ADVANCED CHARACTERIZATION, THERAPEUTICS, AND SYSTEMS IX, PROCEEDINGS OF | 1999年 / 3590卷

关键词：

psoriasis; basal cell carcinoma; squamous cell carcinoma; microscopy; real-time; confocal microscopy; vital microscopy; confocal imaging; skin imaging; skin morphometrics;

D O I：

10.1117/12.351007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Near-infrared confocal reflectance microscopy (CM) provides non-invasive real-time images of thin en-face tissue sections with high resolution and contrast. Imaging of cells, nuclei, other organelles, microvessels, and hair follicles has been possible at resolution comparable to standard histology, to a maximum depth of 250-300 mu m in human skin in vivo. We have characterized psoriasis as a prototype of benign proliferative skin conditions, and non-pigmented skin malignancies in vivo (basal and squamous cell carcinomas -BCC, SCC-) based on their unstained, native histologic features using CM. Our data shows that reflectance CM may potentially diagnose and morphometrically evaluate proliferative skin lesions in vivo.

引用

页码：56 / 65

页数：10

共 8 条

[1] ABNORMAL MATURATION PATHWAY OF KERATINOCYTES IN PSORIATIC SKIN [J].