Understanding enzymic catalysis: The importance of short, strong hydrogen bonds

被引：311

作者：

Gerlt, JA

Kreevoy, MM

Cleland, WW

Frey, PA

机构：

[1] UNIV MINNESOTA, DEPT CHEM, MINNEAPOLIS, MN 55455 USA

[2] UNIV WISCONSIN, INST ENZYME RES, MADISON, WI 53706 USA

[3] UNIV WISCONSIN, DEPT BIOCHEM, MADISON, WI 53706 USA

来源：

CHEMISTRY & BIOLOGY | 1997年 / 4卷 / 04期

关键词：

D O I：

10.1016/S1074-5521(97)90069-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have proposed previously that short, strong hydrogen bonds exist in enzyme active sites and that they are important in explaining enzymic rate enhancements. Here, we defend this proposal and provide evidence for likely changes of hydrogen bond strengths during enzymic catalysis.

引用

页码：259 / 267

页数：9

共 63 条

[1] HYDROGEN-BONDING .7. A SCALE OF SOLUTE HYDROGEN-BOND ACIDITY BASED ON LOG K-VALUES FOR COMPLEXATION IN TETRACHLOROMETHANE
ABRAHAM, MH
GRELLIER, PL
PRIOR, DV
DUCE, PP
MORRIS, JJ
TAYLOR, PJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1989, (06): : 699 - 711
[2] DO ENZYMES STABILIZE TRANSITION-STATES BY ELECTROSTATIC INTERACTIONS OR PK(A) BALANCE - THE CASE OF TRIOSE PHOSPHATE ISOMERASE (TIM)
ALAGONA, G
GHIO, C
KOLLMAN, PA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (39) : 9855 - 9862
[3] PROTON, DEUTERIUM, AND TRITIUM NUCLEAR MAGNETIC-RESONANCE OF INTRA-MOLECULAR HYDROGEN-BONDS - ISOTOPE EFFECTS AND SHAPE OF POTENTIAL-ENERGY FUNCTION
ALTMAN, LJ
LAUNGANI, D
GUNNARSSON, G
WENNERSTROM, H
FORSEN, S
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (26) : 8264 - 8266
[4] VIBRONIC EFFECTS IN HYDROGEN BONDING
ANDERSON, GR
LIPPINCO.ER
[J]. JOURNAL OF CHEMICAL PHYSICS, 1971, 55 (08) : 4077 - &
[5] CALORIMETRIC STUDIES IN HALIDE-HYDROGEN CHLORIDE SYSTEMS
BENOIT, RL
RINFRET, M
DOMAIN, R
[J]. INORGANIC CHEMISTRY, 1972, 11 (11) : 2603 - &
[6] VAN DER WAALS VOLUMES + RADII
BONDI, A
[J]. JOURNAL OF PHYSICAL CHEMISTRY, 1964, 68 (03) : 441 - +
[7] ACIDITIES AND HYDROGEN-BONDING OF PHENOLS IN DIMETHYLSULFOXIDE
BORDWELL, FG
MCCALLUM, RJ
OLMSTEAD, WN
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (08) : 1424 - 1427
[8] STRUCTURE OF CHYMOTRYPSIN TRIFLUOROMETHYL KETONE INHIBITOR COMPLEXES - COMPARISON OF SLOWLY AND RAPIDLY EQUILIBRATING INHIBITORS
BRADY, K
WEI, AZ
RINGE, D
ABELES, RH
[J]. BIOCHEMISTRY, 1990, 29 (33) : 7600 - 7607
[9] PARALLEL ADAPTIVE-CONTROL FOR A TURBOGENERATOR SYSTEM
BROWN, MD
IRWIN, GW
SWIDENBANK, E
HOGG, BW
[J]. CONTROL ENGINEERING PRACTICE, 1994, 2 (03) : 405 - 414
[10] MAJOR CONTRIBUTION OF A CARBOXYMETHYL GROUP TO TRANSITION-STATE STABILIZATION BY CYTIDINE DEAMINASE - MUTATION AND RESCUE
CARLOW, DC
SMITH, AA
YANG, CC
SHORT, SA
WOLFENDEN, R
[J]. BIOCHEMISTRY, 1995, 34 (13) : 4220 - 4224

← 1 2 3 4 5 6 7 →