PI3-K and GSK-3: Akt-ing together with microtubules

被引：71

作者：

Buttrick, Graham J. ^{[1
]}

Wakefield, James G. ^{[1
,2
]}

机构：

[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

[2] Univ Oxford, Life Sci Interface Doctoral Training Ctr, Oxford OX1 3PS, England

来源：

CELL CYCLE | 2008年 / 7卷 / 17期

基金：

英国生物技术与生命科学研究理事会;

关键词：

PI3-kinase; Akt; GSK-3; microtubule; mitosis; centrosome;

D O I：

10.4161/cc.7.17.6514

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphoinositide-3-Kinase (PI3-K) and the downstream kinases Akt and Glycogen Synthase Kinase-3 (GSK-3) have recently been implicated in regulating both microtubule (MT) dynamics and organization. Here we review the role of this signalling pathway in controlling MTs, and explore ways in which the kinases and their substrates may co-operate to spatially regulate MTs in different contexts.

引用

收藏

页码：2621 / 2625

页数：5

相关论文

共 47 条

[1] CLASPs are CLIP-115 and-170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts [J].

Akhmanova, A ;

Hoogenraad, CC ;

Drabek, K ;

Stepanova, T ;

Dortland, B ;

Verkerk, T ;

Vermeulen, W ;

Burgering, BM ;

De Zeeuw, CI ;

Grosveld, F ;

Galjart, N .

CELL, 2001, 104 (06) :923-935

[2] 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase [J].

Alessi, DR ;

Deak, M ;

Casamayor, A ;

Caudwell, FB ;

Morrice, N ;

Norman, DG ;

Gaffney, P ;

Reese, CB ;

MacDougall, CN ;

Harbison, D ;

Ashworth, A ;

Bownes, M .

CURRENT BIOLOGY, 1997, 7 (10) :776-789

[3] Role of translocation in the activation and function of protein kinase B [J].

Andjelkovic, M ;

Alessi, DR ;

Meier, R ;

Fernandez, A ;

Lamb, NJC ;

Frech, M ;

Cron, P ;

Cohen, P ;

Lucocq, JM ;

Hemmings, BA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (50) :31515-31524

[4] Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules [J].

Barros, TP ;

Kinoshita, K ;

Hyman, AA ;

Raff, JW .

JOURNAL OF CELL BIOLOGY, 2005, 170 (07) :1039-1046

[5] Shaggy/GSK-3β kinase localizes to the centrosome and to specialized cytoskeletal structures in Drosophila [J].

Bobinnec, Yves ;

Morin, Xavier ;

Debec, Alain .

CELL MOTILITY AND THE CYTOSKELETON, 2006, 63 (06) :313-320

[6] At regulates centrosome migration and spindle orientation in the early Drosophila melanogaster embryo [J].

Buttrick, Graham J. ;

Beaumont, Luke M. A. ;

Leitch, Jessica ;

Yau, Christopher ;

Hughes, Julian R. ;

Wakefield, James G. .

JOURNAL OF CELL BIOLOGY, 2008, 180 (03) :537-548

[7] INHIBITION OF GLYCOGEN-SYNTHASE KINASE-3 BY INSULIN-MEDIATED BY PROTEIN-KINASE-B [J].

CROSS, DAE ;

ALESSI, DR ;

COHEN, P ;

ANDJELKOVICH, M ;

HEMMINGS, BA .

NATURE, 1995, 378 (6559) :785-789

[8] Microtubule polymerization dynamics [J].

Desai, A ;

Mitchison, TJ .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :83-117

[9] Akt and CHIP coregulate tau degradation through coordinated interactions [J].

Dickey, Chad A. ;

Koren, John ;

Zhang, Yong-Jie ;

Xu, Ya-Fei ;

Jinwal, Umesh K. ;

Birnbaum, Morris J. ;

Monks, Bobby ;

Sun, Mei ;

Cheng, An Q. ;

Pattersonl, Cam ;

Bailey, Rachel M. ;

Dunmore, Judith ;

Soresh, Sareh ;

Leon, Carlos ;

Morgan, Dave ;

Petrucelli, Leonard .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (09) :3622-3627

[10] Cdc42 and Par6-PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization [J].

Etienne-Manneville, S ;

Manneville, JB ;

Nicholls, S ;

Ferenczi, MA ;

Hall, A .

JOURNAL OF CELL BIOLOGY, 2005, 170 (06) :895-901

← 1 2 3 4 5 →