Molecular design and biological potential of galacto-type trehalose as a nonnatural ligand of Shiga toxins

被引：33

作者：

Dohi, H

Nishida, Y ^{[1
]}

Furuta, Y

Uzawa, H

Yokoyama, S

Ito, S

Mori, H

Kobayashi, K

机构：

[1] Nagoya Univ, Grad Sch Engn, Dept Mol Design & engn, Chikusa Ku, Nagoya, Aichi 4648603, Japan

[2] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058565, Japan

[3] Gifu Pharmaceut Univ, Dept Publ Hlth Pharm, Gifu 5028585, Japan

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 03期

关键词：

D O I：

10.1021/ol017135+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] alacto-type trehalose, a "C-4 epimer of trehalose", possesses a stereochemical structure around the alpha(1-1)-linkage analogous to that of the globoblosyl alpha(1-4)-linkage in Gb(2) and Gb(3) ceramides, which are known as the ligands of Shiga toxins produced by pathogenic E. coli. This paper presents evidence supporting the new idea of using a trehalosyl alpha(1-1)-linkage as a substitute for the galactobiosyl alpha(1-4)-linkage.

引用

页码：355 / 357

页数：3

共 20 条

[1] Influence of phospholipid chain length on verotoxin/globotriaosyl ceramide binding in model membranes: Comparison of a supported bilayer film and liposomes [J].