Combined surgery and radiation therapy for squamous cell carcinoma of the hypopharynx

被引：83

作者：

Kraus, DH ^{[1
]}

Zelefsky, MJ ^{[1
]}

Brock, HAJ ^{[1
]}

Huo, J ^{[1
]}

Harrison, LB ^{[1
]}

Shah, JP ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR, DEPT RADIAT THERAPY, BRACHYTHERAPY SERV, NEW YORK, NY 10021 USA

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 1997年 / 116卷 / 06期

关键词：

D O I：

10.1016/S0194-5998(97)70240-7

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Squamous cell carcinoma of the hypopharynx remains a highly lethal disease, This article documents our experience with 132 patients undergoing surgical management of squamous cell carcinoma of the hypopharynx, of whom 80% received postoperative radiation therapy, Local-regional control was obtained in 61% of the patients, Five-year overall and disease-free survival rates were 30% and 41%, respectively. Prognosis was better in patients with limited disease: local disease permitting larynx-sparing surgery, N0/N1 clinical neck, and stage I/II/III disease. Cancer of the hypopharynx remains an aggressive entity associated with poor prognosis, Novel strategies stressing improved local-regional control with prevention of distant metastasis are warranted.

引用

页码：637 / 641

页数：5

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