Making an escape:: Development and function of the Drosophila giant fibre system

被引：121

作者：

Allen, MJ

Godenschwege, TA

Tanouye, MA

Phelan, P ^{[1
]}

机构：

[1] Univ Kent, Dept Biosci, Canterbury CT2 7NJ, Kent, England

[2] Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA

[3] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2006年 / 17卷 / 01期

基金：

英国惠康基金;

关键词：

escape behaviour; synapse; development; plasticity; seizure disorder;

D O I：

10.1016/j.semcdb.2005.11.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Flies escape danger by jumping into the air and flying away. The giant fibre system (GFS) is the neural circuit that mediates this simple behavioural response to Visual stimuli. The sensory signal is received by the giant fibre and relayed to the leg and wing muscle motorneurons. Many of the neurons in the Drosophila GFS are uniquely identifiable and amenable to cell biological, electrophysiological and genetic Studies. Here we review the anatomy and development of this system and highlight its utility for studying many aspects of nervous system biology ranging from neural development and synaptic plasticity to the aetiology of neural disorder. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：31 / 41

页数：11

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[1] Ubiquitin: not just for proteasomes anymore [J].