Use of a phenyl 1-selenogalactofuranoside as a glycosyl donor for the synthesis of galactofuranosyl-containing disaccharides (vol 305, pg 289, 1998)

被引：5

作者：

Johnston, BD

Pinto, BM ^{[1
]}

机构：

[1] Simon Fraser Univ, Dept Chem, Burnaby, BC V5A 1S6, Canada

[2] Simon Fraser Univ, Inst Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada

来源：

CARBOHYDRATE RESEARCH | 1999年 / 315卷 / 3-4期

关键词：

D O I：

10.1016/S0008-6215(99)00024-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of acetylated phenyl 1-seleno-beta-D-galactofuranoside as a glycosyl donor for the sq synthesis of protected D-Galf-beta-(1-->3)-alpha-D-Manp as its methyl or ethylthio glycoside has been demonstrated. Activation of the selenoglycoside over a thioglycoside acceptor by NIS-TfOH is extremely selective and gives the ethylthio disaccharide in 91% yield. The parent disaccharide is found as a terminal and branched unit in the lipopeptidophosphoglycan oligosaccharides of the protozoan Trypanosoma cruzi, the causative agent of Chagas' disease. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：355 / 360

页数：6

共 19 条

[1] N-PENTENYL FURANOSIDES - SYNTHESIS AND GLYCOSIDATION REACTIONS OF SOME GALACTO DERIVATIVES [J].