Stepwise Development of a Homozygous S80P Substitution in Fks1p, Conferring Echinocandin Resistance in Candida tropicalis

被引：43

作者：

Jensen, Rasmus Hare ^{[1
]}

Johansen, Helle Krogh ^{[2
]}

Arendrup, Maiken Cavling ^{[1
]}

机构：

[1] Statens Serum Inst, Mycol Unit, DK-2300 Copenhagen, Denmark

[2] Rigshosp, Copenhagen Univ Hosp, Dept Clin Microbiol, DK-2100 Copenhagen, Denmark

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 01期

关键词：

GLOBAL ANTIFUNGAL SURVEILLANCE; EUCAST TECHNICAL NOTE; CASPOFUNGIN RESISTANCE; REDUCED SUSCEPTIBILITY; NATIONAL SURVEILLANCE; DISK DIFFUSION; C-KRUSEI; ALBICANS; GLABRATA; MUTATIONS;

D O I：

10.1128/AAC.01193-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Three Candida tropicalis isolates were obtained from a patient with acute lymphoblastic leukemia. The first isolate was susceptible to all drug classes, while isolates 2 and 3, obtained after 8 and 8.5 weeks of caspofungin treatment, respectively, were resistant to the three echinocandins. Multilocus sequence genotyping suggested a clonal relation among all isolates. FKS1 sequencing revealed a stepwise development of a heterozygous and finally a homozygous mutation, leading to S80S/P and S80P amino acid substitutions.

引用

页码：614 / 617

页数：4

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