Selective functionalization of 1,2-dihydronaphthalenols leads to a concise, stereoselective synthesis of sertraline.

被引：71

作者：

Lautens, M ^{[1
]}

Rovis, T ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Lash Miller Labs, Toronto, ON, Canada

来源：

TETRAHEDRON | 1999年 / 55卷 / 29期

关键词：

coupling reactions; drugs; physiologically active compounds; stereocontrol;

D O I：

10.1016/S0040-4020(99)00456-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric reductive ring opening of oxabenzonorbornadiene provides dihydronaphthalenols in high ee and good yield. Functionality present in this system can be used to elaborate the core towards a number of targets. As an illustration, a concise stereoselective synthesis of the important antidepressant sertraline is described. (C) 1999 Elsevier Science Ltd. Ail rights reserved.

引用

页码：8967 / 8976

页数：10

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