An efficient, rapid and highly selective preparation of the Wieland-Miescher ketone-9-ethylene ketal

被引:33
作者
Ciceri, P [1 ]
Demnitz, FWJ [1 ]
机构
[1] SANDOZ PHARMA AG,PRECLIN RES,CH-4002 BASEL,SWITZERLAND
关键词
D O I
10.1016/S0040-4039(96)02334-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Reaction of the Wieland-Miescher ketone 1 in ethylene glycol at room temperature using one equivalent of p-toluenesulphonic acid gives the 9-ethylene ketal 2 in greater than or equal to 90% yield and 92% selectivity. Copyright (C) 1996 Published by Elsevier Science Ltd
引用
收藏
页码:389 / 390
页数:2
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