Differential distribution of muscle and skin sympathetic nerve activity in patients with end-stage renal disease

被引:47
作者
Park, Jeanie [1 ]
Campese, Vito M. [2 ]
Nobakht, Niloofar [2 ]
Middlekauff, Holly R. [3 ]
机构
[1] Emory Univ, Sch Med, Dept Med, Div Nephrol, Atlanta, GA 30322 USA
[2] Univ So Calif, Keck Sch Med, Dept Med, Div Nephrol, Los Angeles, CA 90033 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Cardiol, Los Angeles, CA 90095 USA
基金
美国国家卫生研究院;
关键词
dialysis;
D O I
10.1152/japplphysiol.90849.2008
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
distribution of muscle and skin sympathetic nerve activity in patients with end-stage renal disease. J Appl Physiol 105: 1873-1876, 2008. First published October 9, 2008; doi: 10.1152/japplphysiol.90849.2008. End-stage renal disease (ESRD) is characterized by resting sympathetic overactivity. Baseline muscle sympathetic nerve activity (MSNA), which is governed by baroreflexes and chemoreflexes, is elevated in ESRD. Whether resting skin sympathetic nerve activity (SSNA), which is independent from baroreflex and chemoreflex control, is also elevated has never been reported in renal failure. The purpose of this study was to determine whether sympathetic overactivity of ESRD is generalized to include the skin distribution. We measured sympathetic nerve activity to both muscle and skin using microneurography in eight ESRD patients and eight controls. MSNA was significantly (P = 0.025) greater in ESRD (37.3 +/- 3.6 bursts/min) when compared with controls (23.1 +/- 4.4 bursts/min). However, SSNA was not elevated in ESRD (ESRD vs. controls, 17.6 +/- 2.2 vs. 16.1 +/- 1.7 bustst/min, P = 0.61). Similar results were obtained when MSNA was quantified as bursts per 100 heartbeats. We report the novel finding that although sympathetic activity directed to muscle is significantly elevated, activity directed to skin is not elevated in ESRD. The differential distribution of sympathetic outflow to the muscle vs. skin in ESRD is similar to the pattern seen in other disease states characterized by sympathetic overactivity such as heart failure and obesity.
引用
收藏
页码:1873 / 1876
页数:4
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