Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum

被引：150

作者：

Arthan, D

Svasti, J

Kittakoop, P

Pittayakhachonwut, D

Tanticharoen, M

Thebtaranonth, Y

机构：

[1] NSTDA, Natl Ctr Genet Engn & Biotechnol BIOTEC, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Sci, Dept Biochem, Bangkok 10400, Thailand

[3] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

来源：

PHYTOCHEMISTRY | 2002年 / 59卷 / 04期

关键词：

Solanum torvum; Solanaceae; isoflavonoid; steroidal glycoside; antiviral compounds; herpes simplex virus;

D O I：

10.1016/S0031-9422(01)00417-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The C-4 sulfated isoflavonoid, torvanol A (1), and the steroidal glycoside, torvoside H (3), together with the known glycoside, torvoside A (2), were isolated from a MeOH extract of Solanum torvum fruits. Upon enzymatic hydrolysis with beta-glucosidase, torvoside A (2) and torvoside H (3) yielded the corresponding acetal derivatives 4 and 5, respectively. Torvanol A (1), torvoside H (3) and compound 5 exhibited antiviral activity (herpes simplex virus type 1) with IC50 values of 9.6. 23.2 and 17.4 mug/ml, respectively. Compounds 1-5 showed no cytotoxicity (at 50 mug/ml) against BC, KB and Vero cell lines. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：459 / 463

页数：5

共 9 条

[1]

AGRAWAL PK, 1989, HETEROCYCLES, V29, P1895

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