Anti-brain spectrin immunoreactivity in Alzheimer's disease: degradation of spectrin in an animal model of cholinergic degeneration

被引：16

作者：

FernandezShaw, C ^{[1
]}

Marina, A ^{[1
]}

Cazorla, P ^{[1
]}

Valdivieso, F ^{[1
]}

Vazquez, J ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID,CTR BIOL MOL SEVERO OCHOA,MADRID 28049,SPAIN

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1997年 / 77卷 / 01期

关键词：

Alzheimer's disease; brain spectrin; auto antibodies; PC12; cells; cholinergic degeneration;

D O I：

10.1016/S0165-5728(97)00066-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a previous work, we described the existence of anti-brain spectrin auto antibodies in Alzheimer's disease (AD) patients (J. Neuroimmunol. 68 (1996) 39-44). In this report, we further support our previous observations, showing that sera from 9 out of 18 AD patients, but none of 14 control subjects, immunoreacted with spectrin synthesized by PC12 cells. In addition, degradation of brain spectrin was found to be greatly enhanced in the frontal cortex of rats subjected to an animal model of cholinergic degeneration. Our data suggest that spectrin degradation and generation of anti-spectrin auto antibodies may be related to the cholinergic degeneration encountered in AD.

引用

页码：91 / 98

页数：8

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