Massetolides A-H, antimycobacterial cyclic depsipeptides produced by two pseudomonads isolated from marine habitats

被引：119

作者：

Gerard, J

Lloyd, R

Barsby, T

Haden, P

Kelly, MT

Andersen, RJ

机构：

[1] UNIV BRITISH COLUMBIA,DEPT CHEM,VANCOUVER,BC V6T 1Z1,CANADA

[2] UNIV BRITISH COLUMBIA,DEPT OCEANOG EARTH & OCEAN SCI,VANCOUVER,BC V6T 1Z1,CANADA

[3] SEATEK MARINE BIOTECHNOL INC,SURREY,BC V4A 7M4,CANADA

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 03期

关键词：

D O I：

10.1021/np9606456

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Massetolides A-H (1-8), novel cyclic depsipetides, and the known compound viscosin (9) have been isolated from cultures of two Pseudomonas sp. isolated from a marine alga and a marine tube worm, respectively. Massetolide A (1) and viscosin (9) exhibit in vitro antimicrobial activity against Mycobacterium tuberculosis and Mycobacterium avium-intracellulare. Precursor-directed biosynthesis has been used to generate unnatural massetolides 11-13 incorporating nonprotein amino acids.

引用

页码：223 / 229

页数：7

共 16 条

[1] SOLID-PHASE SYNTHESIS OF VISCOSIN, A CYCLIC DEPSIPEPTIDE WITH ANTIBACTERIAL AND ANTIVIRAL PROPERTIES [J].