NSABP-32: Phase III, randomized trial comparing axillary resection with sentinal lymph node dissection: A description of the trial

被引:100
作者
Krag, DN
Julian, TB
Harlow, SP
Weaver, DL
Ashikaga, T
Bryant, J
Single, RM
Wolmark, N
机构
[1] Univ Vermont, Coll Med, Dept Surg, Burlington, VT 05405 USA
[2] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA
[3] Univ Vermont, Coll Med, Dept Med Stat, Burlington, VT 05405 USA
[4] Univ Pittsburgh, Pittsburgh, PA USA
[5] Natl Surg Breast & Bowel Project, Pittsburgh, PA USA
关键词
breast cancer; clinical trial; sentinel node; survival;
D O I
10.1245/ASO.2004.11.909
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The NSABP-32 trial is a randomized, phase III clinical trial to compare sentinel node (SN) resection to conventional axillary dissection in clinically node-negative breast cancer patients. The primary aims of the trial are to determine if removal of only SNs provides survival and regional control equivalent to those of axillary dissection, while diminishing the magnitude of surgically related side effects. In order to ensure consistency of the outcomes for this trial, a standardized method of SN surgery has been utilized for all cases. A secondary aim of the B32 trial is to evaluate whether patients with "occult" metastases in the SNs have worse survival. Accrual is taking place at 73 institutions in North America, and 217 surgeons are enrolling patients.
引用
收藏
页码:208S / 210S
页数:3
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