Leukocyte-endothelial adhesion and angiogenesis in tumors

被引：101

作者：

Jain, RK ^{[1
]}

Koenig, GC ^{[1
]}

Dellian, M ^{[1
]}

Fukumura, D ^{[1
]}

Munn, LL ^{[1
]}

Melder, RJ ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02114

来源：

CANCER AND METASTASIS REVIEWS | 1996年 / 15卷 / 02期

关键词：

adhesion molecules; angiogenesis; leukocyte-endothelial interactions; selectins; integrins;

D O I：

10.1007/BF00437472

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Leukocyte-endothelial adhesion and angiogenesis, until recently considered as separate processes, have been shown to be linked by two recent findings: soluble cellular adhesion molecules (CAMs) involved in leukocyte-endothelial interactions are angiogenic and well known angiogenic molecules secreted by cancer or immune cells can modulate the endothelial CAMs. This molecular link may partially explain why the overall leukocyte-endothelial interaction is often low and heterogeneous in angiogenic tumor vessels and why activated lymphocytes adhere nonuniformly to tumor vessels when injected into the tumor's blood supply.

引用

页码：195 / 204

页数：10

共 63 条

[1] REGULATION OF VCAM-1 EXPRESSION AND INVOLVEMENT IN CELL-ADHESION TO MURINE MICROVASCULAR ENDOTHELIUM [J].