Synthesis and anti-HIV activity of some new aminoadamantane heterocycles

被引：15

作者：

Fytas, G ^{[1
]}

Stamatiou, G ^{[1
]}

Foscolos, GB ^{[1
]}

Kolocouris, A ^{[1
]}

Kolocouris, N ^{[1
]}

Witvrouw, M ^{[1
]}

Pannecouque, C ^{[1
]}

DeClerq, E ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(97)00320-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new class of aminoadamantane heterocycles has been synthesized and examined for anti-HIV activity. Three compounds proved to be active against the replication of HIV-1 in MT-4 cells with an EC50 ranging from 3.6 to 75.2 mu M. No activity was noted with any of the compounds against HIV-2. (C) 1997 Elsevier Science Ltd.

引用

页码：1887 / 1890

页数：4

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