The interaction of 6-mercaptopurine (6-MP) and methotrexate (MTX)

被引：35

作者：

Giverhaug, T ^{[1
]}

Loennechen, T

Aarbakke, J

机构：

[1] Univ Tromso, Inst Pharm, Dept Pharmacol, N-9037 Tromso, Norway

[2] Univ Tromso, Inst Med Biol, N-9037 Tromso, Norway

来源：

GENERAL PHARMACOLOGY | 1999年 / 33卷 / 04期

关键词：

6-mercaptopurine; methotrexate; interaction;

D O I：

10.1016/S0306-3623(99)00022-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The antimetabolites 6-mercaptopurine (6-MP) and metliotrexate (MTX) are the cornerstones in the maintenance treatment of children's acute lymphoblastic leukemia (ALL). The biochemical mechanisms underlying the increased therapeutic efficacy of the combination of these drugs have not yet been elucidated. However, both drugs interact with important pathways, such as purine de novo synthesis (PDNS), purine salvage, and methylation reactions. A review of the mechanistic aspects of the interactions between 6-MP and MTX is given. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：341 / 346

页数：6

共 22 条

[1] Thiopurine biology and pharmacology [J].

Aarbakke, J ;

JankaSchaub, G ;

Elion, GB .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1997, 18 (01) :3-7

[2]

ALAOUI SE, 1997, J NEUROONCOL, V31, P195

[3]

[Anonymous], CANC PRINCIPLES PRAC

[4] THE EFFECT OF METHOTREXATE ON THE BIOAVAILABILITY OF ORAL 6-MERCAPTOPURINE [J].

BALIS, FM ;

HOLCENBERG, JS ;

ZIMM, S ;

TUBERGEN, D ;

COLLINS, JM ;

MURPHY, RF ;

GILCHRIST, GS ;

HAMMOND, D ;

POPLACK, DG .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1987, 41 (04) :384-387

[5]

Bokkerink J P, 1990, Haematol Blood Transfus, V33, P110

[6] SEQUENCE-DEPENDENT, TIME-DEPENDENT AND DOSE-DEPENDENT SYNERGISM OF METHOTREXATE AND 6-MERCAPTOPURINE IN MALIGNANT HUMAN T-LYMPHOBLASTS [J].

BOKKERINK, JPM ;

BAKKER, MAH ;

HULSCHER, TW ;

DEABREU, RRA ;

SCHRETLEN, EDAM ;

VANLAARHOVEN, JPRM ;

DEBRUYN, CHMM .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (20) :3549-3555

[7] CLINICAL EVALUATION OF A NEW ANTIMETABOLITE, 6-MERCAPTOPURINE, IN THE TREATMENT OF LEUKEMIA AND ALLIED DISEASES [J].

BURCHENAL, JH ;

MURPHY, ML ;

ELLISON, RR ;

SYKES, MP ;

TAN, TC ;

LEONE, LA ;

KARNOFSKY, DA ;

CRAVER, LF ;

DARGEON, HW ;

RHOADS, CP .

BLOOD, 1953, 8 (11) :965-999

[8] Apoptosis as a mechanism of cell death induced by different chemotherapeutic drugs in human leukemic T-lymphocytes [J].

daSilva, CP ;

deOliveira, CR ;

deLima, MCP .

BIOCHEMICAL PHARMACOLOGY, 1996, 51 (10) :1331-1340

[9] TEMPORARY REMISSIONS IN ACUTE LEUKEMIA IN CHILDREN PRODUCED BY FOLIC ACID ANTAGONIST, 4-AMINOPTEROYL-GLUTAMIC ACID (AMINOPTERIN) [J].

FARBER, S ;

DIAMOND, LK ;

MERCER, RD ;

SYLVESTER, RF ;

WOLFF, JA .

NEW ENGLAND JOURNAL OF MEDICINE, 1948, 238 (23) :787-793

[10]

Fiskerstrand T, 1997, J PHARMACOL EXP THER, V282, P1305

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