L-DOPA-induced dyskinesia: cellular mechanisms and approaches to treatment

被引：38

作者：

Cenci, M. Angela ^{[1
]}

机构：

[1] Lund Univ, Basal Ganglia Pathophysiol Unit, Dept Expt Med Sci, S-22184 Lund, Sweden

来源：

PARKINSONISM & RELATED DISORDERS | 2007年 / 13卷

关键词：

rodent models; motor complication; dopamine replacement therapy; neuroplasticity;

D O I：

10.1016/S1353-8020(08)70014-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

L-DOPA-induced dyskinesia (LID) is a common complication of the treatment of Parkinson's disease, and its precise mechanisms have long remained unknown. Rodent models of LID provide a tool to dissect the impact of specific factors on the development and expression of dyskinetic movements. This short review will summarize recent findings from rodent studies that have consolidated and considerably expanded our mechanistic understanding of LID. Based on the experimental findings, the review will propose a chart of possible treatment options acting on different pathophysiological levels. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：S263 / S267

页数：5

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