Immunochemical assay of glia-specific antigens as a criterion for blood-brain barrier permeability in rats during acute intoxication with sodium barbital

被引：1

作者：

Ryabukhin, IA

Artemkina, IV

Gurina, OI

Sergienko, VI

Chekhonin, VP

机构：

[1] VP Serbskii Res Ctr Social & Forens Med, Moscow, Russia

[2] Russia Minist Hlth, Inst Physicochem Med, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 05期

关键词：

blood-brain barrier; glia-specific antigens; GFAP AND alpha(2)GP; sodium barbital;

D O I：

10.1023/A:1017904805547

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Enzyme immunoassay showed penetration of two glia-specific antigens, glial fibrillar acid protein GFAP and specific brain glycoprotein alpha (2)GP, through the blood-brain barrier in rats treated with toxic doses of sodium barbital. The permeability of the blood-brain barrier was completely normalized 3 days after treatment. This method can be used in clinical practice for evaluation of the severity of impairment and dynamics of normalization of blood-brain barrier properties during acute intoxication with barbiturates.

引用

页码：502 / 504

页数：3

共 13 条

[1]

CHEKHONIN VP, 1999, IMMUNOCHEMICAL ASSAY, P342

[2] RECENT STUDIES OF THE GLIAL FIBRILLARY ACIDIC PROTEIN [J].