Brain shrinkage in alcoholics: A decade on and what have we learned?

被引：131

作者：

Kril, JJ ^{[1
]}

Halliday, GM

机构：

[1] Univ Sydney, Concord Hosp, Ctr Educ & Res Ageing, Concord 2139, Australia

[2] Prince Wales Med Res Inst, Randwick, NSW 2031, Australia

来源：

PROGRESS IN NEUROBIOLOGY | 1999年 / 58卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0301-0082(98)00091-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain atrophy in alcoholics has been identified using both radiological and pathological techniques, However the magnitude and topography of the atrophy, and the factors which contribute to it, are unclear. This review compares the results of imaging and pathological studies in alcoholics examining variables which may contribute to any discrepancies. We conclude that significant brain damage does occur as a result of alcohol abuse per se, that the damage is regionally specific with the frontal lobes being particularly affected, and that both grey matter and white matter components are damaged. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：381 / 387

页数：7

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