Kinetic analysis of rubidium and thallium as deposited myocardial blood flow tracers in isolated rabbit heart

被引:10
作者
Marshall, RC [1 ]
Taylor, SE [1 ]
PowersRisius, P [1 ]
Reutter, BW [1 ]
Kuruc, A [1 ]
Coxson, PG [1 ]
Huesman, RH [1 ]
Budinger, TF [1 ]
机构
[1] MARTINEZ VET AFFAIRS, NO CALIF HLTH CARE SYST, MARTINEZ, CA 94553 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1997年 / 272卷 / 03期
关键词
perfusion; single positron emission computed tomography; positron emission tomography; potassium analogs; radioisotope;
D O I
10.1152/ajpheart.1997.272.3.H1480
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Evaluation of myocardial perfusion with tracers such as thallium and rubidium is based on the assumption that tissue tracer content is proportional to flow. The purpose of this study was to evaluate the relationship between flow and tissue tracer content of Tl-201 and Rb-83 in the isolated perfused rabbit heart. Rb-83 (86-day half-life), an isotope that is not used clinically, was used as a subsitute for Rb-82 (76-s half-life) to improve the accuracy and precision of data acquisition. The multiple indicator-dilution technique was employed with two independent computational approaches. The first approach explicitly deconvolved Tl-201 and Rb-83 venous concentration curves by the intravascular reference tracer curve. The second approach used a conventional analysis. Both approaches showed that there was more early washout of Rb-83 than Tl-201 and that the heart retained Tl-201 better than Rb-83 within 2 min after isotope introduction. These data indicate that Tl-201 is a better perfusion tracer than Rb-83 in the isolated rabbit heart.
引用
收藏
页码:H1480 / H1490
页数:11
相关论文
共 27 条
[1]  
BASSINGTHWAIGHT.JB, 1993, NUCL CARDIOLOGY STAT, P3
[2]  
Bassingthwaighte J., 1984, HDB PHYSL 2, V4, P549
[3]   REDISTRIBUTION OF MYOCARDIAL TL-201 WITHOUT REPERFUSION - IMPLICATIONS REGARDING ABSOLUTE QUANTIFICATION OF PERFUSION [J].
BERGMANN, SR ;
HACK, SN ;
SOBEL, BE .
AMERICAN JOURNAL OF CARDIOLOGY, 1982, 49 (07) :1691-1698
[4]  
BUDINGER TF, 1975, J NUCL MED, V16, P429
[5]   TRANSCAPILLARY EXCHANGE OF WATER AND OF OTHER SUBSTANCES IN CERTAIN ORGANS OF THE DOG [J].
CHINARD, FP ;
VOSBURGH, GJ ;
ENNS, T .
AMERICAN JOURNAL OF PHYSIOLOGY, 1955, 183 (02) :221-234
[6]   PERMEABILITY OF CAPILLARIES IN VARIOUS ORGANS AS DETERMINED BY USE OF INDICATOR DIFFUSION METHOD [J].
CRONE, C .
ACTA PHYSIOLOGICA SCANDINAVICA, 1963, 58 (04) :292-&
[7]  
GAMEL J, 1973, CIRC RES, V33, P516
[8]   EFFECTS OF REDUCED CORONARY FLOW ON TL-201 ACCUMULATION AND RELEASE IN AN INVITRO RAT HEART PREPARATION [J].
GOLDHABER, SZ ;
NEWELL, JB ;
INGWALL, JS ;
POHOST, GM ;
ALPERT, NM ;
FOSSEL, ET .
AMERICAN JOURNAL OF CARDIOLOGY, 1983, 51 (05) :891-896
[9]   KINETICS OF RUBIDIUM-82 AFTER CORONARY-OCCLUSION AND REPERFUSION - ASSESSMENT OF PATENCY AND VIABILITY IN OPEN-CHESTED DOGS [J].
GOLDSTEIN, RA .
JOURNAL OF CLINICAL INVESTIGATION, 1985, 75 (04) :1131-1137
[10]   MYOCARDIAL TL-201 KINETICS IN NORMAL AND ISCHEMIC MYOCARDIUM [J].
GRUNWALD, AM ;
WATSON, DD ;
HOLZGREFE, HH ;
IRVING, JF ;
BELLER, GA .
CIRCULATION, 1981, 64 (03) :610-618