A different mode of entry by dengue-2 neutralisation escape mutant virus

被引：34

作者：

Lim, HY ^{[1
]}

Ng, ML ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Microbiol, Singapore 119260, Singapore

来源：

ARCHIVES OF VIROLOGY | 1999年 / 144卷 / 05期

关键词：

D O I：

10.1007/s007050050561

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Entry processes were compared between dengue-2 (DEN-2) virus and a DEN-2 neutralisation escape mutant virus in baby hamster kidney (BHK) cells. The mutant virus (mu6B2) was resistant to neutralisation by a monoclonal antibody, MAb 6B2. Infection of BHK cells by the wild-type DEN-2 virus resulted in direct penetration of the virions into the cytoplasm whereas the mutant virus entered cells by endocytosis. The continual presence of the monoclonal antibody might have asserted some pressure for the mutant to adopt a different mode of entry.

引用

页码：989 / 995

页数：7

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