Nanoparticle and targeted systems for cancer therapy

被引：559

作者：

Brannon-Peppas, Lisa ^{[1
]}

Blanchette, James O. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2012年 / 64卷

关键词：

Targeted delivery; Nanoparticles; Cancer therapy; Angiogenesis; Antibodies; CHITOSAN NANOPARTICLES; PLGA NANOPARTICLES; TUMOR ANGIOGENESIS; GENE DELIVERY; PACLITAXEL; PROLIFERATION; STRATEGIES; CONJUGATE; GROWTH;

D O I：

10.1016/j.addr.2012.09.033

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review explores recent work directed towards more targeted treatment of cancer, whether through more specific anti-cancer agents or through methods of delivery. These areas include delivery by avoiding the reticuloendothelial system, utilizing the enhanced permeability and retention effect and tumor-specific targeting. Treatment opportunities using antibody-targeted therapies are summarized. The ability to treat cancer by targeting delivery through angiogenesis is also discussed and antiangiogenic drugs in clinical trials are presented. Delivery methods that specifically use nanoparticles are also highlighted, including both degradable and nondegradable polymers. (C) 2012 Published by Elsevier B.V.

引用

页码：206 / 212

页数：7

共 43 条

[1] An overview of targeted treatments in cancer [J].

Abou-Jawde, R ;

Choueiri, T ;

Alemany, C ;

Mekhail, T .

CLINICAL THERAPEUTICS, 2003, 25 (08) :2121-2137

[2] Toward selection of internalizing antibodies from phage libraries [J].

Becerril, B ;

Poul, MA ;

Marks, JD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 255 (02) :386-393

[3] A PEGylated dendritic nanoparticulate carrier of fluorouracil [J].

Bhadra, D ;

Bhadra, S ;

Jain, S ;

Jain, NK .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 257 (1-2) :111-124

[4] Different strategies for formation of PEGylated EGF-conjugated PEI/DNA complexes for targeted gene delivery [J].

Blessing, T ;

Kursa, M ;

Holzhauser, R ;

Kircheis, R ;

Wagner, E .

BIOCONJUGATE CHEMISTRY, 2001, 12 (04) :529-537

[5] Nanoparticles in cancer therapy and diagnosis [J].

Brigger, I ;

Dubernet, C ;

Couvreur, P .

ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) :631-651

[6] Targeted delivery of chemotherapeutics: tumor-activated prodrug therapy [J].

Chari, RVJ .

ADVANCED DRUG DELIVERY REVIEWS, 1998, 31 (1-2) :89-104

[7] Targeting tumor angiogenesis with gene therapy [J].

Chen, QR ;

Zhang, L ;

Gasper, W ;

Mixson, AJ .

MOLECULAR GENETICS AND METABOLISM, 2001, 74 (1-2) :120-127

[8] VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer:: in vivo studies [J].

Dagar, S ;

Krishnadas, A ;

Rubinstein, I ;

Blend, MJ ;

Önyüksel, H .

JOURNAL OF CONTROLLED RELEASE, 2003, 91 (1-2) :123-133

[9] Tumour vasculature as a target for anticancer therapy [J].

Eatock, MM ;

Schätzlein, A ;

Kaye, SB .

CANCER TREATMENT REVIEWS, 2000, 26 (03) :191-204

[10] Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases [J].

Feng, SS ;

Chien, S .

CHEMICAL ENGINEERING SCIENCE, 2003, 58 (18) :4087-4114

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