Hepatoprotective and antioxidant activity of pentagamavunon-0 against carbon tetrachloride-induced hepatic injury in rats

被引：7

作者：

Nurrochmad, Arief ^{[1
]}

Margono, Supardjan Amir ^{[2
]}

Sardjiman ^{[2
]}

Hakim, Arief Rahman ^{[1
]}

Ernawati ^{[1
]}

Kurniawati, Erna ^{[1
]}

Fatmawati, Erva ^{[1
]}

机构：

[1] Gadjah Mada Univ, Fac Pharm, Dept Pharmacol & Clin Pharm, Sekip Utara Yogyakarta 55281, Indonesia

[2] Gadjah Mada Univ, Fac Pharm, Curcumin Res Ctr, Sekip Utara Yogyakarta 55281, Indonesia

来源：

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2013年 / 6卷 / 06期

关键词：

Hepatoprotective; Antioxidant; Pentagamavunon-0; Carbon tetrachloride; Rats; BIOLOGICAL-ACTIVITIES; OXIDATIVE STRESS; CURCUMIN; LIVER; HEPATOTOXICITY;

D O I：

10.1016/S1995-7645(13)60070-X

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

Objective: To investigate the hepatoprotective and antioxidant activity of pentaganiavunon-0(PGV-0) against CCl4-induced hepatic injury in rats. Methods: The groups of animals were administered with PGV-0 at the doses 2.5, 5, 10, and 20 mg/kg b.w., p.o. once in a day for 6 days and at day 7 the animals were administrated with carbon tetrachloride (CCl4) (20%, 2 mL/kg b.w. in liquid paraffin (i.p.). The effect of PGV-0 on serum transaminase (SGPT), alkaline phosphates (ALP) and total bilirubin were determined in CCl4-induced hepatotoxicity in rats. Further, the effects of PGV-0 on glutathione (GSH) content, catalase (CAT) and NO free radical scavenging activity also were investigated. Results: The results demonstrated that PGV-0 significantly reduced the activity of SGPT, serum ALP and total bilirubin in CCl4 induced rat hepatotoxicity. PGV-0 has effect on the antioxidant and free radical defense system. It prevented the depletion level of GSH and decrease activity of CAT in CCl4-induced liver injury in rats. PGV-0 also demonstrated the free radical scavenger effects on NO free radical scavenging activity with ES value of 32.32 mu M. Conculsion: All of our findings suggests that PGV-0 could protect the liver cells from CCl4-induced liver damages and the mechanism may through the antioxidative effect of PGV-0 to prevent the accumulation of free radicals and protect the liver damage.

引用

页码：438 / 442

页数：5

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