Fully automated synthesis module for the high yield one-pot preparation of 6-[18F]fluoro-L-DOPA

被引：93

作者：

de Vries, EFJ

Luurtsema, G

Brüssermann, M

Elsinga, PH

Vaalburg, W

机构：

[1] Univ Groningen Hosp, PET Ctr, NL-9700 RB Groningen, Netherlands

[2] Nucl Interface Datentech Strahlungsmessgerate Gmb, D-48145 Munster, Germany

来源：

APPLIED RADIATION AND ISOTOPES | 1999年 / 51卷 / 04期

关键词：

D O I：

10.1016/S0969-8043(99)00057-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A fully automated one-pot synthesis of 6-[F-18]fluoro-L-DOPA, an important radiopharmaceutical for studies on the presynaptic dopamine metabolism with positron emission tomography,is described. 6-[F-18]Fluoro-L-DOPA was prepared in high radiochemical yield (33 +/- 4%, c.f.d.) and radiochemical purity (> 99%) in 45 min synthesis time by a fluorodestannylation reaction, followed by acidic removal of the protecting groups. CFCl3 was found to be a better solvent for the fluorodestannylation reaction than CHCl3 or acetonitrile. In CFCl3, [F-18]F-2 was a superior fluorinating agent over [F-18]acetyl hypofluorite. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：389 / 394

页数：6

共 14 条

[1]

BIDA GT, 1984, J NUCL MED, V25, P1327

[2]

CHIRAKAL R, 1986, J NUCL MED, V27, P417

[3]

Dolle F, 1998, J LABELLED COMPD RAD, V41, P105, DOI 10.1002/(SICI)1099-1344(199802)41:2<105::AID-JLCR65>3.0.CO

[4]

2-H

[5]

FIRNAU G, 1984, J NUCL MED, V25, P1228

[6] DOPAMINE VISUALIZED IN THE BASAL GANGLIA OF LIVING MAN [J].

GARNETT, ES ;

FIRNAU, G ;

NAHMIAS, C .

NATURE, 1983, 305 (5930) :137-138

[7] ELECTROPHILIC SYNTHESIS OF 6-[F-18]FLUORO-L-DOPA - USE OF 4-O-PIVALOYL-L-DOPA AS A SUITABLE PRECURSOR FOR ROUTINE PRODUCTION [J].

ISHIWATA, K ;

ISHII, SI ;

SENDA, M ;

TSUCHIYA, Y ;

TOMIMOTO, K .

APPLIED RADIATION AND ISOTOPES, 1993, 44 (04) :755-759

[8]

LEMAIRE C, 1989, Journal of Nuclear Medicine, V30, P752

[9]

LEMAIRE C, 1994, J NUCL MED, V35, P1996

[10]

LUXEN A, 1990, APPL RADIAT ISOTOPES, V41, P275

← 1 2 →