Progression of myelodysplasia to acute lymphoblastic leukaemia: Implications for disease biology

被引：63

作者：

Disperati, P

Ichim, CV

Tkachuk, D

Chun, K

Schuh, AC

Wells, RA

机构：

[1] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

[2] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada

[3] Univ Toronto, Fac Med, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A1, Canada

[4] Univ Toronto, Fac Med, Dept Med, Toronto, ON M5S 1A1, Canada

[5] Univ Hlth Network, Princess Margaret Hosp, Dept Med Oncol & Hematol, Toronto, ON, Canada

[6] Univ Hlth Network, Princess Margaret Hosp, Toronto Med Labs, Toronto, ON, Canada

[7] Toronto Sunnybrook Reg Canc Ctr, Myelodysplast Syndrome Program, Toronto, ON M4N 2M5, Canada

来源：

LEUKEMIA RESEARCH | 2006年 / 30卷 / 02期

关键词：

myelodysplastic syndrome; acute lymphoblastic leukaemia; acute myelogenous leukaemia; stem cell; leukaemogensis; progression;

D O I：

10.1016/j.leukres.2005.06.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myelodysplastic syndrome (MDS) comprises a group of clonal haematopoietic disorders characterized by peripheral blood cytopenias, bone marrow hypercellularity, and abnormal blood cell differentiation. Approximately 30% of cases of MDS eventually progress to acute myelogenous leukemia (AML), while progression of MDS into acute lymphoblastic leukemia (ALL) is rare. In this report, we describe a case of MDS that progressed to ALL, and review the 21 previously reported cases of MDS to ALL transformation. We review the cancer stem cell model and its application to these disorders, and discuss the implications of the rarity of transformation of MDS to ALL for the biology of MDS and the pathogenesis of ALL. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：233 / 239

页数：7

共 60 条

[1] CLONALITY OF CELL-POPULATIONS IN REFRACTORY-ANEMIA USING COMBINED APPROACH OF GENE LOSS AND X-LINKED RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM METHYLATION ANALYSES [J].