Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus

被引：62

作者：

Gentry, Daniel R. ^{[1
]}

McCloskey, Lynn ^{[1
]}

Gwynn, Michael N. ^{[1
]}

Rittenhouse, Stephen F. ^{[1
]}

Scangarella, Nicole ^{[1
]}

Shawar, Ribhi ^{[1
]}

Holmes, David J. ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, UP1345, ID CEDD, Dept Microbiol, Collegeville, PA 19426 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 12期

关键词：

D O I：

10.1128/AAC.00915-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Retapamulin MICs of >= 2 mu g/ml were noted for 6 of 5,676 S. aureus recent clinical isolates evaluated. The ABC proteins VgaAv and VgaA were found to be responsible for the reduced susceptibility to pleuromutilins exhibited by these six isolates.

引用

页码：4507 / 4509

页数：3

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