Sepsis biomarkers: an omics perspective

被引：26

作者：

Liu, Xiao ^{[1
,2
]}

Ren, Hui ^{[2
]}

Peng, Daizhi ^{[1
]}

机构：

[1] Third Mil Med Univ, Inst Burn Res, Southwest Hosp, State Key Lab Trauma Burns & Combined Injury, Chongqing 400038, Peoples R China

[2] Third Mil Med Univ, Sch Nursing, Chongqing 400038, Peoples R China

来源：

FRONTIERS OF MEDICINE | 2014年 / 8卷 / 01期

关键词：

sepsis; biomarker; genomics; transcriptomics; proteomics; metabolomics; C-REACTIVE PROTEIN; CRITICALLY-ILL PATIENTS; TNF-ALPHA; PROMOTER POLYMORPHISM; EPIGENETIC REGULATION; PROTEOMIC ANALYSIS; SEPTIC SHOCK; EXPRESSION; SERUM; GENE;

D O I：

10.1007/s11684-014-0318-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. This review describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics, and metabolomics. The combination of these technologies can help refine the diagnosis of sepsis. This review paper serves as a reference for future studies that employ an integrated, multi- omics approach to disease identification.

引用

页码：58 / 67

页数：10

共 76 条

[1] Genetic polymorphisms and sepsis
Arcaroli, J
Fessler, MB
Abraham, E
[J]. SHOCK, 2005, 24 (04): : 300 - 312
[2] Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review
Backes, Yara
van der Sluijs, Koenraad F.
Mackie, David P.
Tacke, Frank
Koch, Alexander
Tenhunen, Jyrki J.
Schultz, Marcus J.
[J]. INTENSIVE CARE MEDICINE, 2012, 38 (09) : 1418 - 1428
[3] Role of high mobility group box 1 in inflammatory disease: Focus on sepsis
Bae, Jong-Sup
[J]. ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (09) : 1511 - 1523
[4] IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants
Baier, R. John
Loggins, John
Yanamandra, Krishna
[J]. BMC MEDICINE, 2006, 4 (1)
[5] TLR4 and TNF-α polymorphisms are associated with an increased risk for severe sepsis following burn injury
Barber, RC
Aragaki, CC
Rivera-Chavez, FA
Purdue, GF
Hunt, JL
Horton, JW
[J]. JOURNAL OF MEDICAL GENETICS, 2004, 41 (11) : 808 - U1
[6] An operational definition of epigenetics
Berger, Shelley L.
Kouzarides, Tony
Shiekhattar, Ramin
Shilatifard, Ali
[J]. GENES & DEVELOPMENT, 2009, 23 (07) : 781 - 783
[7] Epigenetics and Bacterial Infections
Bierne, Helene
Hamon, Melanie
Cossart, Pascale
[J]. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2012, 2 (12):
[8] Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure
Boomer, Jonathan S.
To, Kathleen
Chang, Kathy C.
Takasu, Osamu
Osborne, Dale F.
Walton, Andrew H.
Bricker, Traci L.
Jarman, Stephen D., II
Kreisel, Daniel
Krupnick, Alexander S.
Srivastava, Anil
Swanson, Paul E.
Green, Jonathan M.
Hotchkiss, Richard S.
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 306 (23): : 2594 - 2605
[9] Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis
Bozza, Fernando A.
Salluh, Jorge I.
Japiassu, Andre M.
Soares, Marcio
Assis, Edson F.
Gomes, Rachel N.
Bozza, Marcelo T.
Castro-Faria-Neto, Hugo C.
Bozza, Patricia T.
[J]. CRITICAL CARE, 2007, 11 (02)
[10] Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels
Brenner, Thorsten
Rosenhagen, Claudia
Steppan, Jochen
Lichtenstern, Christoph
Weitz, Juergen
Bruckner, Thomas
Martin, Eike O.
Hoffmann, Ursula
Weigand, Markus A.
Hofer, Stefan
[J]. MEDIATORS OF INFLAMMATION, 2010, 2010

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