Total lymphocyte count, hemoglobin, and delayed-type hypersensitivity as predictors of death and AIDS illness in HIV-1-infected women receiving highly active antiretroviral therapy

被引:44
作者
Anastos, K
Shi, QH
French, AL
Levine, A
Greenblatt, RM
Williams, C
DeHovitz, J
Delapenha, R
Hoover, DR
机构
[1] Montefiore Med Ctr, Womens Interagcy HIV Study, Bronx, NY 10467 USA
[2] Lincoln Med & Mental Hlth Ctr, Bronx, NY 10451 USA
[3] New York Med Coll, Valhalla, NY 10595 USA
[4] Cook Cty Hosp, Rush Med Coll, Chicago, IL USA
[5] Univ So Calif, Los Angeles, CA USA
[6] Univ Calif San Francisco, San Francisco, CA 94143 USA
[7] NIAID, NIH, Bethesda, MD USA
[8] Hlth Sci Ctr, Brooklyn, NY USA
[9] Howard Univ, Med Ctr, Washington, DC USA
[10] Rutgers State Univ, Dept Stat, New Brunswick, NJ USA
[11] Rutgers State Univ, Inst Hlth, Hlth Care Policy & Aging Res, New Brunswick, NJ USA
关键词
HIV; highly active antiretroviral therapy; survival; disease progression; total lymphocyte count;
D O I
10.1097/00126334-200404010-00008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Total lymphocyte count (TLC) and hemoglobin level have been suggested as useful and inexpensive parameters to indicate need for HAART in settings in which CD4(+) cell counts are unavailable. If delayed-type hypersensitivity (DTH) response predicts clinical response in persons using highly active antiretroviral therapy (HAART), it may also prove useful in resource-poor settings. Objective: To examine whether TLC, hemoglobin, and DTH response observed prior to initiation of HAART predict post-HAART clinical response. Design: Prospective cohort study. Participants: 873 women in the Women's Interagency HIV Study. Measurements: TLC, hemoglobin, CD4(+) cell counts, and DTH testing using mumps, candida, and tetanus toxoid antigens, performed within 1 year prior to HAART initiation; death; self-report of initiation of HAART use and AIDS-defining illness (ADI). Results: Three different multivariate analyses were performed: 2 models that excluded CD4(+) cell count and assessed TLC at either <850 or <1250 cells/muL, and 1 model that excluded TLC and included CD4(+) <200 cells/muL. TLC <850, TLC <1250, CD4(+) <200 cells/muL, anergy to DTH testing, hemoglobin <10.6 g/dL, and a pre-HAART report of ADI were each consistently independently associated both with death and with incident ADI. Log likelihood chi(2) values suggested similar power among the 3 models in predicting both death and incident ADI. Conclusions: Pre-HAART TLC, hemoglobin level, anergy to DTH testing, and clinical disease each independently predicted morbidity and death after HAART initiation. These findings support the use of TLC to guide decision-making for HAART initiation and suggest that further study of TLC, hemoglobin level, and DTH responses as an indication to provide HAART may be useful in resource-limited settings.
引用
收藏
页码:383 / 392
页数:10
相关论文
共 37 条
[1]   Risk of progression to AIDS and death in women infected with HIV-1 initiating highly active antiretroviral treatment at different stages of disease [J].
Anastos, K ;
Barrón, Y ;
Miotti, P ;
Weiser, B ;
Young, M ;
Hessol, N ;
Greenblatt, RM ;
Cohen, M ;
Augenbraun, M ;
Levine, A ;
Muñoz, A .
ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (17) :1973-1980
[2]   Usefulness of total lymphocyte count in monitoring highly active antiretroviral therapy in resource-limited settings [J].
Badri, M ;
Wood, R .
AIDS, 2003, 17 (04) :541-545
[3]   The Women's Interagency HIV Study [J].
Barkan, SE ;
Melnick, SL ;
Preston-Martin, S ;
Weber, K ;
Kalish, LA ;
Miotti, P ;
Young, M ;
Greenblatt, R ;
Sacks, H ;
Feldman, J .
EPIDEMIOLOGY, 1998, 9 (02) :117-125
[4]  
BERHANE K, UNPUB WOMENS INTERAG
[5]  
*BHIVA, 2001, HIV MED, V2, P276
[6]  
BIRX DL, 1993, J ACQ IMMUN DEF SYND, V6, P1248
[7]   DELAYED-TYPE HYPERSENSITIVITY SKIN TESTING PREDICTS PROGRESSION TO AIDS IN HIV-INFECTED PATIENTS [J].
BLATT, SP ;
HENDRIX, CW ;
BUTZIN, CA ;
FREEMAN, TM ;
WARD, WW ;
HENSLEY, RE ;
MELCHER, GP ;
DONOVAN, DJ ;
BOSWELL, RN .
ANNALS OF INTERNAL MEDICINE, 1993, 119 (03) :177-184
[8]   INSTABILITY OF DELAYED-TYPE HYPERSENSITIVITY SKIN-TEST ANERGY IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J].
CAIAFFA, WT ;
GRAHAM, NMH ;
GALAI, N ;
RIZZO, RT ;
NELSON, KE ;
VLAHOV, D .
ARCHIVES OF INTERNAL MEDICINE, 1995, 155 (19) :2111-2117
[9]   GUIDELINE FOR FLOW CYTOMETRIC IMMUNOPHENOTYPING - A REPORT FROM THE NATIONAL-INSTITUTE-OF-ALLERGY-AND-INFECTIOUS-DISEASES, DIVISION OF AIDS [J].
CALVELLI, T ;
DENNY, TN ;
PAXTON, H ;
GELMAN, R ;
KAGAN, J .
CYTOMETRY, 1993, 14 (07) :702-715
[10]   A randomised, open-label comparison of three highly active antiretroviral therapy regimens including two nucleoside analogues and indinavir for previously untreated HIV-1 infection: the OzCombo1 study [J].
Carr, A ;
Chuah, J ;
Hudson, J ;
French, M ;
Hoy, J ;
Law, M ;
Sayer, D ;
Emery, S ;
Cooper, DA .
AIDS, 2000, 14 (09) :1171-1180