White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study

被引:371
作者
Medina, D
DeToledo-Morrell, L
Urresta, F
Gabrieli, JDE
Moseley, M
Fleischman, D
Bennett, DA
Leurgans, S
Turner, DA
Stebbins, GT
机构
[1] Rush Univ, Sch Med, Dept Neurosci, Chicago, IL 60612 USA
[2] Rush Univ, Med Ctr, Dept Psychol, Chicago, IL 60612 USA
[3] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA
[4] Stanford Univ, Dept Psychol, Palo Alto, CA 94304 USA
[5] Stanford Univ, Dept Radiol, Palo Alto, CA 94304 USA
关键词
aging; cognition; dementia; fractional anisotropy; MRI;
D O I
10.1016/j.neurobiolaging.2005.03.026
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Diffusion tensor imaging (DTI) can detect, in vivo, the directionality of molecular diffusion and estimate the microstructural integrity of white matter (WM) tracts. In this Study, we examined WM changes in patients with Alzheimer's disease (AD) and in subjects with amnestic mild cognitive impairment (MCI) who are at greater risk for developing AD. A DTI index of WM integrity, fractional anisotropy (FA), was calculated in 14 patients with probable mild AD, 14 participants with MCI and 21 elderly healthy controls (NC). Voxel-by-voxel comparisons showed significant regional reductions of FA in participants with MCI and AD compared to controls in multiple posterior white matter regions. Moreover, there was Substantial overlap of locations of regional decrease in FA in the MCI and AD groups. These data demonstrate that white matter changes occur in MCI, prior to the development of dementia. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:663 / 672
页数:10
相关论文
共 77 条
[1]   The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease [J].
Arnold, Steven E. ;
Hyman, Bradley T. ;
Flory, Jill ;
Damasio, Antonio R. ;
Van Hoesen, Gary W. .
CEREBRAL CORTEX, 1991, 1 (01) :103-116
[2]   White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging [J].
Barber, R ;
Scheltens, F ;
Gholkar, A ;
Ballard, C ;
McKeith, I ;
Ince, P ;
Perry, R ;
O'Brien, J .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1999, 67 (01) :66-72
[3]   In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease [J].
Baron, JC ;
Chételat, G ;
Desgranges, B ;
Perchey, G ;
Landeau, B ;
de la Sayette, V ;
Eustache, F .
NEUROIMAGE, 2001, 14 (02) :298-309
[4]   Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's diesase [J].
Bartzokis, G ;
Sultzer, D ;
Lu, PH ;
Neuchterlein, KH ;
Mintz, J ;
Cummings, JL .
NEUROBIOLOGY OF AGING, 2004, 25 (07) :843-851
[5]   Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease [J].
Bartzokis, G .
NEUROBIOLOGY OF AGING, 2004, 25 (01) :5-18
[6]   White matter structural integrity in healthy aging adults and patients with Alzheimer disease - A magnetic resonance imaging study [J].
Bartzokis, G ;
Cummings, JL ;
Sultzer, D ;
Henderson, VW ;
Nuechterlein, KH ;
Mintz, J .
ARCHIVES OF NEUROLOGY, 2003, 60 (03) :393-398
[7]   Inferring microstructural features and the physiological state of tissues from diffusion-weighted images [J].
Basser, PJ .
NMR IN BIOMEDICINE, 1995, 8 (7-8) :333-344
[8]  
Basser PJ, 1996, J MAGN RESON SER B, V111, P209, DOI [10.1006/jmrb.1996.0086, 10.1016/j.jmr.2011.09.022]
[9]   ESTIMATION OF THE EFFECTIVE SELF-DIFFUSION TENSOR FROM THE NMR SPIN-ECHO [J].
BASSER, PJ ;
MATTIELLO, J ;
LEBIHAN, D .
JOURNAL OF MAGNETIC RESONANCE SERIES B, 1994, 103 (03) :247-254
[10]   Mild cognitive impairment [J].
Bennett, DA .
CLINICS IN GERIATRIC MEDICINE, 2004, 20 (01) :15-+