Physical activity, cognitive activity, and cognitive decline in a biracial community population

被引:100
作者
Sturman, MT
Morris, MC
de Leon, CFM
Bienias, JL
Wilson, RS
Evans, DA
机构
[1] Rush Univ, Med Ctr, Rush Inst Healthy Aging, Chicago, IL 60612 USA
[2] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA
[3] Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA
[4] Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL 60612 USA
[5] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
[6] Rush Univ, Med Ctr, Dept Psychol, Chicago, IL 60612 USA
[7] John H Stroger Jr Hosp Cook Cty, Dept Med, Chicago, IL USA
关键词
D O I
10.1001/archneur.62.11.1750
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Findings from studies investigating whether physical activity reduces the risk of cognitive decline in old-age have been inconsistent. Objective: To examine whether participation in physical activity by older adults reduces the rate of cognitive decline after accounting for participation in cognitively stimulating activities. Design: A prospective population study conducted from August 1993 to January 2003, with an average follow-up of 6.4 years. Setting: A biracial community population on the south side of Chicago. Participants: Participants were 4055 community-dwelling adults 65 years and older who were able to walk across a small room and had participated in at least 2 of the 3 follow-up assessments. Main Outcome Measure: Annual rate of cognitive change as measured by-a global cognitive score, which consisted of averaged standardized scores from 4 cognitive tests. Results: In a mixed model adjusted for age, sex, race, and education, each additional physical activity hour per week was associated with a slower rate of cognitive decline by 0.0007 U/y (P = .04). However, with further adjt stments (1) for participation in cognitive activities (P =. 0006, P = .10), (2) for depression and vascular diseases ((beta) over cap = .0005, P = .19), and (3) by excluding participants whose global cognitive score at baseline was at or below the 10th percentile ((beta) over cap = .0002, P = .45), the coefficients were smaller and no longer statistically significant. Conclusion: These data do not support the hypothesis that physical activity alone protects against cognitive decline among older adults.
引用
收藏
页码:1750 / 1754
页数:5
相关论文
共 40 条
  • [1] Walking and dementia in physically capable elderly men
    Abbott, RD
    White, LR
    Ross, GW
    Masaki, KH
    Curb, JD
    Petrovitch, H
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 292 (12): : 1447 - 1453
  • [2] USE OF BRIEF COGNITIVE TESTS TO IDENTIFY INDIVIDUALS IN THE COMMUNITY WITH CLINICALLY DIAGNOSED ALZHEIMERS-DISEASE
    ALBERT, M
    SMITH, LA
    SCHERR, PA
    TAYLOR, JO
    EVANS, DA
    FUNKENSTEIN, HH
    [J]. INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1991, 57 (3-4) : 167 - 178
  • [3] Predictors of cognitive change in older persons: MacArthur studies of successful aging
    Albert, MS
    Savage, CR
    Blazer, D
    Jones, K
    Berkman, L
    Seeman, T
    Rowe, JW
    [J]. PSYCHOLOGY AND AGING, 1995, 10 (04) : 578 - 589
  • [4] Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function
    Arvanitakis, Z
    Wilson, RS
    Bienias, JL
    Evans, DA
    Bennett, DA
    [J]. ARCHIVES OF NEUROLOGY, 2004, 61 (05) : 661 - 666
  • [5] Design of the Chicago Health and Aging Project (CHAP)
    Bienias, Julia L.
    Beckett, Laurel A.
    Bennett, David A.
    Wilson, Robert S.
    Evans, Denis A.
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2003, 5 (05) : 349 - 355
  • [6] LEARNING CAUSES SYNAPTOGENESIS, WHEREAS MOTOR-ACTIVITY CAUSES ANGIOGENESIS, IN CEREBELLAR CORTEX OF ADULT-RATS
    BLACK, JE
    ISAACS, KR
    ANDERSON, BJ
    ALCANTARA, AA
    GREENOUGH, WT
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) : 5568 - 5572
  • [7] Health habits and risk of cognitive impairment and dementia in old age: A prospective study on the effects of exercise, smoking and alcohol consumption
    Broe, GA
    Creasey, H
    Jorm, AF
    Bennett, HP
    Casey, B
    Waite, LM
    Grayson, DA
    Cullen, J
    [J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, 1998, 22 (05) : 621 - 623
  • [8] Incidence of Alzheimer disease in a biracial urban community - Relation to apolipoprotein E allele status
    Evans, DA
    Bennett, DA
    Wilson, RS
    Bienias, JL
    Morris, MC
    Scherr, PA
    Hebert, LE
    Aggarwal, N
    Beckett, LA
    Joglekar, R
    Berry-Kravis, E
    Schneider, J
    [J]. ARCHIVES OF NEUROLOGY, 2003, 60 (02) : 185 - 189
  • [9] SOCIAL AND LEISURE ACTIVITIES AND RISK OF DEMENTIA - A PROSPECTIVE LONGITUDINAL-STUDY
    FABRIGOULE, C
    LETENNEUR, L
    DARTIGUES, JF
    ZARROUK, M
    COMMENGES, D
    BARBERGERGATEAU, P
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1995, 43 (05) : 485 - 490
  • [10] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN
    FOLSTEIN, MF
    FOLSTEIN, SE
    MCHUGH, PR
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) : 189 - 198