Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage

被引：161

作者：

Verdi, JM

Bashirullah, A

Goldhawk, DE

Kubu, CJ

Jamali, M

Meakin, SO

Lipshitz, HD

机构：

[1] John P Robarts Res Inst, London, ON N6A 5K8, Canada

[2] Univ Western Ontario, Dept Physiol, London, ON, Canada

[3] Univ Western Ontario, Dept Biochem, London, ON, Canada

[4] Hosp Sick Children, Program Dev Biol, Inst Res, Toronto, ON M5G 1X8, Canada

[5] CALTECH, Div Biol, Pasadena, CA 91125 USA

[6] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5G 1X8, Canada

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 18期

关键词：

D O I：

10.1073/pnas.96.18.10472

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a phosphotyrosine-binding domain and a proline-rich region (PRR) that functions as an SH3-binding domain, Here we show that there are at least four human NUMB isoforms and that these serve two distinct developmental functions in the neuronal lineage: differentiation (but not proliferation) is promoted by human NUMB protein isoforms with a type I (short) PRR. In contrast, proliferation (but not differentiation) is directed by isoforms that have a type II (long) PRR, The two types of PRR may promote distinct intracellular signaling pathways downstream of the NOTCH receptor during mammalian neurogenesis.

引用

页码：10472 / 10476

页数：5

共 23 条

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