Solubility of paracetamol in pure solvents

被引：320

作者：

Granberg, RA ^{[1
]}

Rasmuson, ÅC ^{[1
]}

机构：

[1] Royal Inst Technol, Dept Chem Engn & Technol, SE-10044 Stockholm, Sweden

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 1999年 / 44卷 / 06期

关键词：

D O I：

10.1021/je990124v

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The solubility of paracetamol (4-hydroxyacetanilide) in 26 solvents in the temperature range from -5 to + 30 degrees C is reported. Paracetamol has a very low solubility in nonpolar and chlorinated hydrocarbons such as toluene and carbon tetrachloride whereas the solubility is very high in solvents of medium polarity such as N,N-dimethylformamide, dimethyl sulfoxide, and diethylamine. Paracetamol is soluble in alcohols, but the solubility decreases with an increase in the length of the carbon chain in the n-alcohol homologous series (methanol to l-octanol). The solubility of paracetamol in water is much lower than in other polar solvents such as the alcohols. The ideal solubility of paracetamol is calculated, and the activity coefficient in the saturated solutions is estimated.

引用

页码：1391 / 1395

页数：5

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