Novel nortriterpenes from Phlomis umbrosa

被引：24

作者：

Liu, Pu ^{[1
,3
]}

Yao, Zhi ^{[2
]}

Zhang, Wen ^{[1
]}

Takaishi, Yoshihisa ^{[4
]}

Duan, Hong-Quan ^{[1
]}

机构：

[1] Tianjin Med Univ, Basic Med Res Ctr Tianjin, Sch Pharmaceut Sci, Tianjin 300070, Peoples R China

[2] Tianjin Med Univ, Dept Immunol, Tianjin 300070, Peoples R China

[3] Henan Univ Sci & Technol, Chem Engn & Pharmaceut Coll, Luoyang 471003, Peoples R China

[4] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 07期

关键词：

Phlomis umbrosa; nortriterpenoid; cytotoxic activity; X-ray analysis;

D O I：

10.1248/cpb.56.951

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

We isolated 8 novel 28-noroleanane-derived spirocyclic triterpenoids with unusual skeleton structures, phlomisone (1), phlomistetraol A (2), phlomistetraol B (3), phlomistetraol C (4), phlomispentaol (5), phlomishexaol A (6), phlomishexaol B (7), and phlomisin (8), from the ethanol extract of Phlomis umbrosa rhizomes. Their structures were elucidated on the basis of spectroscopic methods, including ID, 2D nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HR-MS), and X-ray analyses. Compounds 1-3, 5, and 7 exhibited positive cytotoxic activities against the carcinoma cell lines Hela and L929 in vitro, and these bioactive data suggested that the C-18 and C-21 positions had oxygenated functions that can improve the activity of the compound.

引用

页码：951 / 955

页数：5

共 12 条

[1]

Two new triterpene and a new nortriterpene glycosides from Phlomis viscosa [J].