Kinesin-8 molecular motors: putting the brakes on chromosome oscillations

被引：46

作者：

Gardner, Melissa K. ^{[1
]}

Odde, David J. ^{[1
]}

Bloom, Kerry ^{[2
]}

机构：

[1] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA

[2] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

来源：

TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 07期

关键词：

D O I：

10.1016/j.tcb.2008.05.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies suggest that the human Kinesin-8 molecular motor Kif18A has a role in chromosome congression. Specifically, these studies find that Kif18A promotes chromosome congression by attenuating chromosome oscillation magnitudes. Together with recent modeling work, in vitro studies, and the analysis of in vivo yeast data, these reports reveal how Kinesin-8 molecular motors might control chromosome oscillation amplitudes by spatially regulating the dynamic instability of microtubule plus-ends within the mitotic spindle.

引用

页码：307 / 310

页数：4

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